题 目：Non-canonical Nucleic Acids 报告人：Prof. Naoki Sugimoto (杉本直己) 日本甲南（Konan）老员工物分子工程先端研究所 主任 时 间：2017年8月25日周五下午4:00 地 点：仙林化学楼H201报告厅 Abstract: TThe critical role of the nucleic acids, DNA and RNA, is to store and process the genetic information including all of the information that is necessary for life. In 1953, Watson and Crick demonstrated that DNA forms a double helix via Watson-Crick base pairs. Half a century after the discovery of the double helix, the Human Genome Project (HGP) identified the almost 3.2 billion base pairs in the entire human genome. The HGP also showed that repetitive DNA sequences including dinucleotide and trinucleotide repeats as well as telomeric and centromeric sequences are widely distributed in the human genome. Most of this repetitive DNA can potentially fold into non-canonical structures. From this perspective, clarifying not only the primary structure (sequence) of nucleic acids but also thermodynamic and kinetic analyses of the higher-order structures and structure-function relationships of nucleic acids are essential for understanding the reactions that underlie biological processes and diseases. In this lecture, I will show the importance of behaviors of non-canonical structures such as the G-quadruplexes on the gene expression. Selected References （2013-2017）: N. Sugimoto et al., J. Am. Chem. Soc., 2017, 139, 7768, Nucleic Acids Res. 2017, 45, in press, Nucleic Acids Res. 2017, 45, 461, Angew. Chem. Int. Ed. 2016, 55, 14315, Angew. Chem. Int. Ed. 2016, 55, 899, Anal. Chem. 2016, 88, 7137, Anal. Chem. 2016, 88, 1984, Angew. Chem. Int. Ed. 2015, 54, 905, Nucleic Acids Res. 2015, 43, 10114, Anal. Chem. 2015, 87, 7628, Chem. Rev. 2014, 114, 2733, Nucleic Acids Res. 2014, 42, 12949, Nucleic Acids Res. 2014, 42, 8831, J. Am. Chem. Soc. 2013, 135, 9412, Angew. Chem. Int. Ed. 2013, 52, 13774, Angew. Chem. Int. Ed. 2013, 52, 5522, Nucleic Acids Res. 2013, 41, 8581, Nucleic Acids Res. 2013, 41, 6222, and so on. 简介: 杉本直己，1979年和1985年在京都大学获学士和博士学位。1985-1988年在美国罗切斯特大学作博士后， 回日本后任职于日本甲南大学，于1994年晋升教授。2003年至今任甲南老员工物分子工程先端研究所主任。他曾任日本化学会生物分子论坛主席（1998-2001）、生物功能化学分会主席（2011-2013）。研究兴趣包括：生物化学、生物材料、生物纳米工程、分子设计、生物功能化学及生物科技等。他是日本宫崎、名古屋、大阪、东北，中国南开、天津等多所大学客座教授。他曾获多项荣誉，如日本化学会创新工作奖（2008），JSPS科学推广奖（2013），日本配位化学会的贡献奖（2014），欧洲化学会议主题报告奖（2016）。2007年起任核酸研究领域顶级杂志核酸研究（Nucleic Acids Res.）杂志编委。 联系人：周俊 副教授 jun.zhou@nju.edu.cn |