报告题目：Can Organic Synthesis Impact Human Health? Biography： Ohyun Kwon received her BS and MS in chemistry (with Eun Lee) from Seoul National University in 1991 and 1993, respectively. She came to the US in 1993 and obtained her PhD (with Samuel J. Danishefsky) from Columbia University in 1998. After a postdoctoral stint in the laboratory of Stuart L. Schreiber at Harvard University, she began her independent career in 2001 as an Assistant Professor at the University of California, Los Angeles (UCLA). In 2008, she was promoted to Associate Professor with tenure at UCLA and Full Professor in 2013. Her research involves the chemistry of nitrodienes, the development of chiral phosphines, phosphine-mediated and -catalyzed reactions and their application to natural product synthesis and chemical biology.
Abstract: The phosphinocatalysis reactions that my group has developed have produced structurally varied heterocycles of immense value for numerous practical applications. To illustrate the utility of these heterocycles, my group has been engaged in chemical genetic studies, resulting in the identification of the following bio-modulators: (1) inhibitors of the enzymes GGTase�I and Rab GGTase; (2) an anti-arrhythmic agent (named “efsevin”) to rescue zebrafish tremblor mutant; (3) an inhibitor (named “aplexone”) of cholesterol biosynthesis that is more potent than Pfizer’s Lipitor; (4) compounds inhibiting cell migration and cell invasion; (5) interferon γ�like compounds that augment innate immune responses of macrophages; (6) inhibitors of cytotoxic T cell lytic granule exocytosis; and (7) inhibitors of serine hydrolases that are specific for platelet-activating factor acetylhydrolases 1b2 and 1b3 (PAFAH1b2/3). Chemical biological studies related with these molecules will be presented during the talk. 欢迎参加！ |