题 目：Functional Supramolecular Systems Based on Host-Guest Interactions and Nucleic Acid Chemistry 报 告：Janarthanan Jayawickramarajah教授，Tulane University 地 点：化学楼 H201 时 间：2016年7月6号（星期三）下午4:00 邀请人： 强琚莉 (jjl@nju.edu.cn，王乐勇（lywang@nju.edu.cn） Abstract: This talk will focus on the molecular recognition and supramolecular chemistry phenomena associated with functional and programmed assemblies in water. The first portion of the seminar will detail our forays into the construction (and photophysical evaluation) of multi-porphyrin containing nanostructures assembled through inter alia hydrophobically-driven, β-cyclodextrin (β-CD)-based, host-guest interactions. During the second segment, the seminar will focus on our efforts towards the generation of a new class of "smart" protein-binders/inhibitors, termed DNA-small molecule chimeras (DCs), which possess the interesting capacity of being activated non-covalently by specific nucleic acid sequences. As a result of the inter-disciplinary nature of our work, a variety of studies will be presented, ranging from organic synthesis to spectroscopic (including FRET, UV-vis, circular dichrosim, and fluorescence anisotropy experiments) and microscopic (including TEM, STM, and AFM) studies. I will also provide a brief background about Tulane University and the Chemistry Department. 报告人简介： A. Contact Information Dr. Janarthanan Jayawickramarajah Associate Professor Department of Chemistry Tulane University 2015 Percival Stern Hall New Orleans, LA, 70118, USA Phone: (504) 862-3580 FAX: (504) 865-5596 Email: jananj@tulane.edu B. Professional Preparation Associate Professor, Department of Chemistry, Tulane University (July 2013 � present) Full Program Member of the Tulane Cancer Center (June 2012 � present) Contributing Member of the Tulane Cancer Center (October 2008 � May 2012) Assistant Professor, Department of Chemistry, Tulane University (August 2007 � present) Postdoctoral Associate, Department of Chemistry, Yale University (September 2005 � July 2007) Advisor: Professor Andrew D. Hamilton Functional self-assemblies in water using orthogonal synthetic and bioinspired supramolecular interactions Ph.D. Chemistry, University of Texas at Austin (August 2005) Advisor: Professor Jonathan L. Sessler Dissertation: Self-assembly of functionalized synthetic nucleic acid bases B.S. Chemistry with honors, and minor in Anthropology University of North Carolina at Chapel Hill (June 2000) Advisor: Professor Holden H. Thorp Honors Thesis: Probing solvent viscosity effects on the catalytic oxidation of DNA by tris(bipyridine) ruthenium (III) C) Other Experience and Professional Memberships in Tulane Univ. Member of the Chemistry Graduate Recruitment Committee, (2008 � present) Chairman of the Tulane Chemistry Department Seminar Series, (2009 � present) Member of the Organic Chemistry Faculty Search Committee, (2010 � 2011) Faculty Member of the Tulane Honor Board, (2010 � 2012) Member of the Tulane Health Professions Committee, (2012 � 2014) Faculty Advisor for the Tulane American Chemical Society Student Chapter, (2012 � present) |