题 目：AIE Probes for Biomedical Applications 报告人：Prof. Bin Liu (刘斌 ) 新加坡国立大学 Department of Chemical and Biomolecular Engineering National University of Singapore (NUS) 地 点：化学楼H201报告厅 时 间：2016年6月6号（星期一）上午10:00 联系人：成义祥教授 (yxcheng@nju.edu.cn) 摘要：Fluorogens with aggregataion-induced emission (AIE) characteristics have recently aroused significant research interest. The unique AIE process offers a straightforward solution to the aggregation-caused quenching problem faced by traditional fluorophores. In this talk, we summarize our recent AIE work to highlight the utility of AIE effect in the development of new fluorescent bioprobes, which allows the use of highly concentrated fluorogens for biosensing and imaging. The simple design and fluorescence turn-on feature of the molecular AIE bioprobes offer direct visualization of specific analytes and biological processes in aqueous media with higher sensitivity and better accuracy than traditional fluorescence turn-off probes. The AIE dot-based bioprobes with different formulations and surface functionalities show advanced features over quantum dots and small molecule dyes, such as large absorptivity, high luminosity, excellent biocompatibility, free of random blinking, and strong photobleaching resistance. In addition, our recent discovery that AIE fluorogens with enhanced reactive oxygen species generation in solid state further expanded their applications to cancer therapy. These features enable cancer cell detection, long term cell tracing, and tumor imaging in a noninvasive and high contrast manner. 报告人简介：Bin Liu received BS degree from Nanjing University and Ph.D. degree from the National University of Singapore (NUS) before her postdoctoral training at the University of California, Santa Barbara. She joined the Chemical and Biomolecular Engineering Department of NUS in late 2005. She was promoted to Associate Professor in 2010 and named Dean’s Chair Professor in 2014. Her current research focuses on organic nanomaterials for biomedical and energy applications. Dr. Liu has received many highly prestigious awards, including the NUS Young Investigator Award 2006, National Science and Technology Young Scientist Award 2008, Defense Innovative Research Program Award 2010, L’Oréal Women in Science National Fellowship 2011, NUS Young Researcher Award 2013, Asia Rising Star 2013, Invited Lecturer of Asia Excellence, Japanese Polymer Society 2013, SNIC-BASF Materials Award 2014, Singapore National Research Foundation Investigatorship 2014 and Materials in Society Lectureship (Elsevier) 2015. Recently, she was named as The World’s Most Influential Minds and the Top 1% Highly Cited Researchers in Materials Science by Thomson Reuters. Dr. Liu is the Fellow of the Royal Society of Chemistry and serves as the Associate Editor for Polymer Chemistry. 有同学想申请刘斌教授课题组博士或博士后，联系成义祥或刘斌(cheliub@nus.edu.sg)，然后确定面谈时间。 欢迎参加！ 化员工物学与新药创制研究所 分子有机化学研究中心 国家863计划新材料MO源研究开发中心 |