报告题目：Chemical Approaches to Probe the Functions of Protein O-GlcNAcylation 报告人：Prof. Jiaoyang Jiang(蒋骄杨) Email: jiaoyang.jiang@wisc.edu 时间：2015年6月30日（星期二）上午10：00 地点：化学楼三楼报告厅 联系人：王欢（wanghuan@nju.edu.cn） 摘要： O-GlcNAc transferase (OGT) is an essential human enzyme that catalyzes the addition of a single N-acetylglucosamine to serine or threonine residues of intracellular proteins. This unique post-translational modification, named O-GlcNAcylation, modulates a wide range of signaling pathways linked to glucose metabolism and its abnormality has been linked to many human diseases. In this talk, I will discuss recent results on the molecular mechanism of O-GlcNAcylation, a new class of OGT inhibitors with an unprecedented mechanism of inhibition, and the novel proteolytic activity of OGT in the maturation process of Host Cell Factor 1 (HCF-1) an important regulator of the cell cycle. These studies facilitate rational design of chemical tools to dissect the biological functions of OGT and O-GlcNAcylation. 报告人简介： Jiaoyang Jiang (蒋骄杨) 2013.08 � Present: Assistant Professor, University of Wisconsin-Madison 2008.11 � 2013.07: Postdoctoral Researcher, Harvard Medical School (Dr. Suzanne Walker) 2004.09 � 2008.09: Graduate Researcher, Brown University (Dr. David Cane) 1999.09 � 2004.05: Undergraduate Researcher, University of Science and Technology of China (Dr. Zhiyong Wang) References 1. Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. ACS Chem Biol. 2015 Mar 18. [Epub ahead of print]. 2. Lazarus, MB*; Jiang, J*; Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S. (*equal contribution) Science 2013, 342, 1235-9. 3. Lazarus, MB*; Jiang, J*; Gloster, TM; Zandberg, WF; Whitworth, GE; Vocadlo, DJ; Walker, S. (*equal contribution) Nature Chemical Biology 2012, 8, 966-8. 4. Jiang, J*; Lazarus, MB*; Pasquina, L; Sliz, P; Walker, S. (*equal contribution) Nature Chemical Biology 2012, 8, 72-7. 5. Lazarus, MB; Nam, Y; Jiang, J; Sliz, P; Walker, S. Nature 2011, 469, 564-7. 配位化学国家重点实验室 太阳集团tcy8722 |