报告题目：Adventures in Molecular Recognition: Dynamic Combinatorial Chemistry and Supramolecular Nanotubes 报告人：Prof. Dr. Jeremy K. M. Sanders，剑桥大学副董事长，英国皇家科公司院士 时间: 2014年6月5号（星期四）上午10:30 地点：费彝民楼104报告厅 邀请人：潘毅教授 EDUCATION and EXPERIENCE: Email: jkms@cam.ac.uk Homepage：http://www-sanders.ch.cam.ac.uk 1969 B.Sc. (Chemistry), Imperial College, London 1972 Ph.D. (Chemistry), University of Cambridge 1972-73 Research Associate in Pharmacology, Stanford University, U.S.A. 1973-96 Demonstrator, then Lecturer then Reader in Chemistry, Cambridge， 1996- Professor of Chemistry, University of Cambridge 2000-06 Head, Department of Chemistry, University of Cambridge 2006-10 Deputy Vice-Chancellor, University of Cambridge 2009-11 Head, School of Physical Sciences, University of Cambridge Jeremy Sanders教授，现为英国剑桥大学教授，英国皇家科公司Fellow (相当于中国科公司院士)，世界著名超分子化学家，其研究领域涉及有NMR波谱尤其在类固醇和微生物储藏聚合物生物物理化学研究，动态组合化学和超分子化学等领域；在拓扑化学研究比如轮烷，索烃，分子绳结，以及超分子纳米管方面做出世界级研究工作。曾经担任剑桥大学化学系系主任，剑桥大学副董事长。并担任过许多国际著名期刊的编委，包括英国皇家化学会《New J. Chem.》副主编，《Chem. Soc. Rev.》科学主编，《.J. Am. Chem. Soc.》编辑顾问委员会委员等。 并获得诸多的国际著名奖项。 摘要： Classical organic synthesis, which relies on design and kinetically-controlled reactions, has a limited ability to create new kinds of molecules that are capable of molecular recognition. Therefore we have developed dynamic combinatorial chemistry, which is inspired by biological evolution and the mammalian immune system. We create complex equilibrating mixtures from which a template can gather around itself a successful host despite the complexity of the reaction mixture. This host can be selected, amplified, isolated and identified: we design the experiment, not the molecule. We can also exploit self-templating to create complex folded catenanes and knots. This provides the synthetic chemist with a selection approach to molecular recognition that complements the traditional design approach. It can change the way we think about synthesis and provide us with a way of exploring how complex systems respond to external stimuli. We will also discuss hydrogen-bonded supramolecularnanotubes: they self-assemble in solution from simple building blocks, and display rich host�guest chemistry, including the ability to dissolve C60 in organic solvents and to rearrange to give a different receptor in response to the presence of C70.
Key References Dynamic combinatorial chemistry, Chemical Reviews, 2006, 106, 3652. Evolution of dynamic combinatorial chemistry, Accounts Chem. Res., 2012, 45, 2211�2221. Dynamic combinatorial syntheses of catenanes in water, Proc. Natl Acad. Sci. USA, 2009, 106, 10466; J. Am. Chem. Soc., 2011, 133, 3198. Discovery of an organic trefoil knot, Science, 2012, 338, 783�785. Helical supramolecular nanotubes, Angew. Chemie Intl. Edn., 2007, 46, 194. Host�Guest chemistry and thermodynamics of supramolecular nanotubes and related systems, J. Am. Chem. Soc., 2012, 134, 566�573.. | 